Coronary artery disease (CAD) affects 17.6 million Americans and results in nearly half a million deaths per year. The estimated indirect and direct costs of CAD are expected to triple over the next two decades from $273 to $881 billion. Despite access to sophisticated diagnostic imaging tests at a cost of $6 billion per year, over 1,000,000 US patients are referred to unnecessary invasive catheterization procedures, resulting in patient risk and a staggering financial burden to the US healthcare system.
HeartMetrics has developed an automated non-invasive diagnostic algorithm to rapidly quantify coronary blood flow from a standard computed tomography angiography (CTA) image of the heart. This technology (Transluminal Attenuation Flow Encoding) TAFE TM is based upon contrast dispersion fluid dynamics and helps identify coronary disease that causes a reduction of blood flow to the heart muscle. Identification of vessel specific ischemia greatly facilitates decisions about whether patients should be referred to the catheterization laboratory/operating room for invasive therapy or be managed by medications only.
Dr. Lardo is Associate Professor of Medicine and Biomedical Engineering at Johns Hopkins University. He is a recognized expert in cardiovascular computed tomography (CT) and magnetic resonance imaging (MRI) imaging with a focus on the development of novel translational methods to assess myocardial pathophysiology and deliver cardiac therapies.
Dr. Lardo has over 60 issued/pending patents worldwide and has successfully commercialized medical imaging technology derived from his intellectual property
HeartMetrics is his third medical start-up derived from his JHU-based intellectual property
Dr. Mittal is Professor of Mechanical Engineering and Medicine at Johns Hopkins University. He is a recognized international expert in computational fluid dynamics and cardiovascular fluid dynamics.
Dr. Mittal has 5 issued/pending patents.